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Twins also share many aspects of their environment (e.g., uterine environment, parenting style, education, wealth, culture, community) because they are born into the same family.

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After the link to mosquitos and their parasites were identified in the early twentieth century, mosquito control measures such as widespread use of the insecticide DDT, swamp drainage, covering or oiling the surface of open water sources, indoor residual spraying and use of insecticide treated nets was initiated.

Prophylactic quinine was prescribed in malaria endemic areas, and new therapeutic drugs, including chloroquine and artemisinins, were used to resist the scourge.

Twins are a valuable source for observation because they allow the study of environmental influence and varying genetic makeup: "identical" or monozygotic (MZ) twins share nearly 100% of their genes, which means that most differences between the twins (such as height, susceptibility to boredom, intelligence, depression, etc.) are due to experiences that one twin has but not the other twin.

"Fraternal" or dizygotic (DZ) twins share only about 50% of their genes, the same as any other sibling.

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