She, along with her sisters Patricia and Rosanna and her then sister-in-law Courteney Cox, attended the premiere of David's short film Arquette died during the early morning hours of September 11, 2016 at the age of 47.
The actress/performer passed while surrounded by family with David Bowie's "Starman" playing in the background.
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She won an Emmy award for her performance in the show and three Golden Globe nominations from 2006 to 2008.
In 1987, Patricia appeared in slasher fantasy film A Nightmare on Elm Street 3: Dream Warriors for her role as Kristen Parker.
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Born a biological male, Alexis gravitated toward the feminine at an early age.
"I remember Alexis growing up, and we'd be in school in kindergarten, and they'd say, ' Get in line, boys here, girls here.' Alexis would always get in the girls' line," sister Patricia Arquette explained to the In addition to her work, Arquette also supported her siblings' endeavors.